The term Whetstone can refer to:

• Whetstone, London - A London district.
• Whetstone, Cumbria - A place in Cumbria.
• Whetstone, Leicestershire - A place in Leicestershire.
• Whetstone, Arizona - A place in the U.S.A .
• Whetstone (tool) - A stone used for sharpening knives and other cutting tools.
• Whetstone (benchmark) - A benchmark for measuring computing power.
• Whetstone (brook) - A brook running through Craftsbury, Vermont, USA.
• Operation Whetstone, a nuclear test program in the 1960s.