Wheels can mean:

• The plural of wheel.
• Wheels, a novel by Arthur Hailey.
• Wheels, an operating system for the Commodore 64.
• Wheels magazine
• WHEELS, a bus service in the San Francisco Bay Area, California
• WHEELS, a suburban bus service operated by contractors for New Jersey Transit
• Derek "Wheels" Wheeler, a character from the Degrassi series played by Neil Hope