Valproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the UK and US for the treatment of the manic episodes of bipolar disorder, and in the US for the treatment of epilepsy, chronic pain associated with neuropathy, and migraine headaches. Its chemical name is sodium hydrogen bis(2-propylpentanoate). The extended release formulation allows for a single daily dose.

Branded Formulations

• Brazil - Depakote® by Abbott Laboratories
• Canada - Epival® by Abbott Laboratories.
• United Kingdom - Depakote® by Sanofi-Aventis
• United States - Depakote® and Depakote ER® (Extended Release) by Abbott Laboratories

References

• RXList.com: Depakote (Divalproex sodium)
• British National Formulary Edition 50
• Drugs.com Advanced Consumer Info: Valproic Acid
• Depakote (Official) - Abbott Laboratories

Anticonvulsants | Mood stabilizers | Teratogens