, , , | PubChem = 5538 | DrugBank = APRD00362 | chemical_formula = C₂₀H₂₈O₂ | molecular_weight = 300.435 g/mol | bioavailability = | protein_bound = > 95% | metabolism = | elimination_half-life = 0.5-2 hours | pregnancy_category = | legal_status = | routes_of_administration = }} Tretinoin is a retinoic acid (vitamin A) drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel (brand name Retin-A®). It is used by some as a hair loss treatment.

Clinical Pharmacology

Although the exact mode of action of tretinoin is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.

Uses

Tretinoin is most commonly used as a form of acne treatment. It was the first retinoid developed for this type of topical use. It is also used for hair loss treatment.

Side effects and sunscreen use

When used, dryness of the affected skin may occur. More sensitive patients may also experience redness, scaling, itching, and burning. Sun exposure may be detrimental to its intended effects. Application of sunscreen while using tretinoin is strongly recommended.

See also

• Baldness treatments

External links

• Thomson MicroMedix listing for Tretinoin Topical
• BASF Technical Information

Dermatological preparations | Trétinoïne