Thrombomodulin is an integral membrane protein expressed on the surface of epithelial cells.

The protein has a molecular weight of 74kDa, and consists of a single chain with 5 distinct domains.

It functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stochiometric complex with thrombin. This raises the speed of protein C activation thousandfold. Thrombomodulin-bound thrombin has no procoagulant effect. The TT-complex also inhibits fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI) into its active form.

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Coagulation system