Sweet Sixteen can mean:

• sweet sixteen (birthday), a party thrown in honor of a girl's sixteenth birthday in America
• Sweet Sixteen (album), an album by The Huntingtons
• Sweet Sixteen (Royal Trux), a 1997 album by Royal Trux
• Sweet Sixteen (Billy Idol song)
• A song by Feeder, famed as the theme song from computer game Gran Turismo
• A song by Irish group The Fureys
• Sweet Sixteen (movie), a 2002 film directed by Ken Loach
• Sweet Sixteen (1983 film), a 1983 film directed by Jim Sotos
• Sweet Sixteen (1928 film), featuring Reginald Sheffield
• Sweet Sixteen (NCAA Basketball Tournament), the final sixteen teams left in the NCAA Men's Division I Basketball Championship or the NCAA Women's Division I Basketball Championship
• SWEET16, an interpreted language in the Apple II computer that emulated a virtual 16-bit microprocessor
• A 16 gauge long recoil operated shotgun designed by John M. Browning