Subplate neurons are among the first generated neurons in the mammalian Cerebral Cortex (Kostovic & Rakic, 1980). These neurons disappear during postnatal development and are important in establishing the correct wiring (McConnell et al. 1989, Ghosh & Shatz, 1992) and functional maturation (Kanold et al. 2003) of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects (McQuillen & Ferriero 2005).

References

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Kostovic I, Rakic P.; J Neurocytol. 1980 Apr;9(2):219-42 ^*

McConnell SK, Ghosh A, Shatz CJ; Science. 1989 Sep 1;245(4921):978-82 ^*

Ghosh A, Shatz CJ; Science. 1992 Mar 13;255(5050):1441-3 ^*

Kanold PO, Kara P, Reid RC, Shatz CJ.; Science. 2003 Jul 25;301(5632):521-5 ^*

McQuillen PS, Ferriero DM; Brain Pathol. 2005 Jul;15(3):250-60 ^*

See also

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• Cerebral Cortex
• Cortical column
• Cerebral hemisphere