Structural genomics consists in the determination of the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography, NMR spectroscopy or computational approaches such as homology modelling.

As opposed to traditional structural biology, the determination of a protein structure through a structural genomics effort often comes before anything is known regarding the protein function. This raises new challenges in structural bioinformatics consisting in determining a protein function from its 3D structure.

One of the important aspects of structural genomics is the emphasis on high throughput determination of protein structures. This is performed in dedicated centers of structural genomics.

External links

Structural genomics centers

• Structural Genomics Consortium
• Protein Structure Initiative
• Northeast Structural Genomics Consortium
• The Midwest Center for Structural Genomics
• Berkeley Structural Genomics Center
• Center for Eukaryotic Structural Genomics
• Yeast Structural Genomics (Genomique Structurale de la levure)
• RIKEN Structural Genomics/Proteomics Initiative
• Structural Genomics of Pathogenic Protozoa
• The Joint Center for Structural Genomics
• Mycobacterium tuberculosis Structural Genomics Consortium
• New York Structural Genomics Research Consortium (NYSGRC)
• NJCST Initiative in Structural Genomics and Bioinformatics
• Structural Genomics at Brookhaven Natl. Labs
• Structure to Function Pilot Project: CARB
• The Southeast Collaboratory for Structural Genomics
• Toronto Structural Proteomics Consortium
• Protein Structure Factory
• Oxford Protein Production Facility

Genomics