Smart bomb has several meanings:

• In weapons, a smart bomb is a precision-guided munition.
• In video games, particularly scrolling shoot 'em ups, a smart bomb is a weapon of limited supply which damages or kills all enemies within a large area, possibly the entire screen.
• Smart Bomb is a 2005 puzzle video game for the PSP.
• SMARTBOMB: The Quest for Art, Entertainment, and Big Bucks in the Videogame Revolution is a 2005 book about the battle between Sony and Microsoft during the sixth generation of video game consoles.
• "Smartbomb" is a musical recording by BT that appeared in the 2001 music video game FreQuency.
• "Smartbomb" is also an anti-cancer treatment that can burrow into cancer, seal it off and kill the cancer cells while not damaging healthy cells.
• "Smart Bomb Interactive" is a video game development company with studio locations in Salt Lake City and San Francisco.