Scrub or scrubs may refer to:

• Scrubs (TV series), a television sitcom based on characters working in a hospital
• Scrubs (clothing), a kind of clothing designed for medical staff performing surgery
• "No Scrubs", a song by TLC on their 1999 album Fanmail
• Scrub (gaming), a video game player who loses because he is unable, or refuses, to use certain powerful characters or techniques
• First scrub, a particular member of a surgical team
• Deku Scrub, a fictional race in The Legend of Zelda
• Scrubber, an industrial gas-pollution control device
• Low-lying vegetation predominant in scrubland. See also shrub.
• To scrub audio or video content is to move the currently viewed or heard part of it backwards or forwards in order to locate something in it quickly.