Referred pain is an unpleasant sensation localised to an area separate from the site of the causative injury or other painful stimulation. Often, referred pain arises when a nerve is compressed or damaged at or near its origin. In this circumstance, the sensation of pain will generally be felt in the territory that the nerve serves, even though the damage originates elsewhere.

A common example occurs in intervertebral disc herniation, in which a nerve root arising from the spinal cord is compressed by adjacent disc material. Although pain may arise from the damaged disc itself, pain will also be felt in the region served by the compressed nerve (for example, the thigh, knee, or foot). Relieving the pressure on the nerve root may ameliorate the referred pain, provided that permanent nerve damage has not occurred.

A similar mechanism may be responsible for some instances of the phantom limb syndrome in amputees.

In another classic example of referred pain, patients who are suffering a myocardial infarction (heart attack) feel pain in their left arm. Another example of referred pain is the common "ice cream headache" or "brain freeze."

In cases of damage to viscera, referred pain may be due to convergence of visceral nerves that innervate the damaged organs with somatic nerves that innervate sections of skin. Because a neuron from the organ and one from the skin may form a synapse with the same projection neuron in the dorsal horn, input from either neuron will be interpreted the same way by it and all neurons further up the pathway. Since the brain is more "accustomed" to receiving sensation from the peripheral structure than from the viscera, it may interpret the pain as originating from the former. Thus there is an array of diseases that cause damage to organs and which produce characteristic patterns of pain in unrelated places in the body's periphery.

Despite the proliferation of literature on the mechanisms of referred pain, it is a process that is still not well understood.

Pain