Legend

Primary groups

• Blue: Stimulants generally increase in potency to the upper left.
• Red: Depressants generally increase in potency to the lower right.
• Green: "Hallucinogens" are psychedelic to the left, dissociative to the right, generally less predictable down and to the right, and generally more potent towards the bottom.
• Pink: Antipsychotics are generally more sedative/tranquilizing to the right.

Secondary groups

• Cyan (light blue): Overlap of Stimulants (Blue) and Psychedelic hallucinogens (Green) — Primary psychedelics exhibit a stimulant effect
• Yellow : Overlap of Depressants (Red) and Dissociative hallucinogens (Green) — Primary dissociatives exhibit a depressant effect
• Lavender: Overlap of Stimulants (Blue) and Antipsychotics (Pink) - The modern non-sedating antidepressants.
• Salmon: Overlap of Depressants (Red) and Antipsychotics (Pink) - The older sedating antidepressants and anxiolytics.

Tertiary groups

• Magenta (purple): Overlap of Stimulants (Blue) and Depressants (Red) — Example: nicotine exhibits effects of both.
• White: Overlap of Stimulants, Depressants and Hallucinogens — Example: THC exhibits effects of all three sections.
• Sky-blue: Overlap of Stimulants, Psychedelic hallucinogens and Antipsychotics - The empathogens / entactogens.
• Peach: Overlap of Depressants, Dissociative hallucinogens and Antipsychotics

Quaternary group

• Light-pink: Center overlap of all four sections (Stimulants, Depressants, Hallucinogens and Antipsychotics) - Cannabis, containing both THC and CBD exhibits a mix of all sections, leaning towards the hallucinogen section due to THC being the primary constituent.

A brief history of drug use

While medicinal use plays a very large role, it has been suggested that the urge to alter one's consciousness is as primary as the drive to satiate thirst, hunger or sexual desire.

Some may point a finger to marketing, availability or the pressures of modern life as to why humans use so many psychoactives in their daily lives, but one only has to look back at history, or even to children with their desire for spinning, swinging, sliding amongst other activities to see that the drive to alter one's state of mind is universal.

This relationship is not limited to humans. A surprising number of animals consume different psychoactive plants and animals, berries and even fermented fruit, clearly becoming intoxicated. Traditional legends of sacred plants often contain references to animals that introduced man to their use.

Biology suggests an evolutionary connection between psychoactive plants and animals, as to why these chemicals and their receptors exist within the nervous system.

Other psychoactive drugs

• Aphrodisiacs
  • Bremelanotide

• In a broader sense also:
  • Antiemetics
  • Analgesics
  • Antiepileptics

Ways psychoactive drugs affect the brain

1. Prevent The Action Potential From Starting
   • Lidocaine, TTX (they bind to voltage-gated sodium channels, so no action potential begins even when a generator potential passes threshold)
2. Neurotransmitter Synthesis
   • Increase - L-Dopa, tryptophan, choline (precursors)
   • Decrease - PCPA (inhibits synthesis of 5HT)
   • Causes increased sensitivity to the five senses, due to an increasing number of signals being sent to the brain.
3. Neurotransmitter Packaging
   • Increase - MAO Inhibitors
   • Decrease - Reserpine (pokes holes in the synaptic vesicles of catecholamines)
4. Neurotransmitter Release
   • Increase - Black Widow Spider venom (ACh)
   • Decrease - Botulinum Toxin (ACh), Tetanus (GABA)
5. Agonists - Mimic the original neurotransmitters and activate the receptors
   • Muscarine, Nicotine (ACh)
   • AMDA, NMDA (Glu)
   • Alcohol, Benzodiazepines (GABA)
6. Antagonists - Bind to the receptor sites and block activation
   • Atropine, Curare (ACh)
   • PCP (Glu)
   • Caffeine (adenosine)
7. Prevent ACh Breakdown
   • Insecticides, Nerve Gas
8. Prevent Reuptake
   • Cocaine (DA), Amphetamines (E)
   • Tricyclics, SSRIs (5-HT, NE)

- based on information taught in NSC 201, Vanderbilt University ''

Philosophy and Morality of psychoactive drugs

For thousands of years, people have studied psychoactive drugs, both by observation and ingestion. However, humanity remains bitterly divided regarding psychoactive drugs, and their value and use has long been an issue of major philosophical and moral contention, even to the point of war (the Opium Wars being a prime example of a war being fought over psychoactives). A majority of youths and adults consume one or more psychoactive drugs. In the West, the most common by numbers of users are caffeine, alcohol, and nicotine, in that order. Most people accept restrictions on some and the prohibition of others, especially the "hard" drugs, which are generally illegal in most countries.

Because so many consumers want to reduce or eliminate their own use, many professionals, self-help groups, and businesses specialize in that field, with varying degrees of success. Many parents attempt to influence the actions and choices of their children.

Debate continues over whether each psychoactive drug being considered is or is not spiritual, sinful, therapeutic, poisonous, ethical, immoral, effective, risky, responsible, recreational, a weapon to use against enemies, a boost to the economy, etc. These attitudes can often be deeply rooted in philosophical and/or religious beliefs, making it difficult to reach consensus or agreement on the proper moral and philosophical stance regarding psychoactive drugs. A major point of contention regards the role of government, whether it should, in respect to each drug, remain neutral, make use safer, educate for abstention, educate for moderation, regulate trade, require a prescription, restrict promotion, prohibit altogether, alter penalties, change enforcement, and so on.

See also

• Antipsychotics
• Stimulants
• Depressants
• Hallucinogens
• Entheogens
• Medication
• Recreational drug use
• Drug addiction
• Demand reduction
• Freedom of thought
• Substance abuse
• Poly drug use
• List of street names of drugs
• Arguments for and against drug prohibition
• Neuropsychopharmacology
• Psychedelics, dissociatives and deliriants

References