Propafenone ( proe-pa-FEEN-none)(brand name Rythmol®) is a class Ic anti-arrhythmic medication. It is used in the treatment of atrial and ventricular arrhythmias.

It works by slowing the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitablity of the cells.

Propafenone is metabolized primarily in the liver. Because of its short half-life, it requires dosing two or three times daily to maintain steady blood levels. The long-term safety of propafenone is unknown. Because it is structurally similar to another dangerous anti-arrhythmic medicine, flecainide, caution should be exercised in its use. Flecainide has been shown to increase the occurrence of dangerous arrhythmias, primarily in patients with underlying heart disease.

Side effects attributed to propafenone include hypersensitivity reactions, lupus-like syndrome, agranulocytopenia, CNS disturbances such as dizziness, lightheadedness, G.I. upset, metallic taste and bronchospasm.

External links

• Rythmol (manufacturer's website)
• Propafenone (patient information)

Antiarrhythmic agents | Propafenona