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A pre-replication complex is a protein complex that forms at the origin of replication during the initiation step of DNA replication.
The following factors make up the complex:
- A helicase such as dnaA, which unwinds the DNA ahead of the replication fork.
- A primase such as dnaG, which generates an RNA primer to be used in DNA replication.
- A DNA holoenzyme, which is actually a complex of enzymes that performs the actual replication.
"Pre-replication complex"