Potassium-sparing diuretic refers to diuretic drugs that do not promote the secretion of potassium into the urine. They are used as adjunctive therapy, together with other drugs, in the treatment of hypertension and management of congestive heart failure.

Potassium-sparing diuretics do not share any obvious chemical similarities, except for the steroid-structure of the aldosterone antagonists. Those in clinical use include:

• Amiloride
• Triamterene
• Aldosterone antagonists
  • Spironolactone
  • Eplerenone

References

• Block JH, Beale JM. "Organic Medicinal and Pharmaceutical Chemistry" 11th edition. Lippincott Williams & Wilkins. 2004.

Diuretics | Pharmacologic agents | Cardiology