Plague has many different meanings:

• The disease bubonic plague, caused by the bacterium Yersinia pestis
• A pestilence - an extensive outbreak of an infectious disease
• A Pandemic
• The Black Death, also known as The Black Plague, the great 14th century disease (and its reprises until the 18th century).
• Plagues of Egypt, the biblical plagues
• The Plague, a novel by Albert Camus
• Capacitor plague, failing capacitors on PC motherboard
• Plague (wrestler) is the stage name of a US wrestler
• The Plague (band), New Zealand band