Pipestone can refer to:

• Pipestone Area High School, the public high school in Pipestone, Minnesota.
• Pipestone, Minnesota, a town in the state of Minnesota, USA.
• Pipestone County, Minnesota, the county in which the town of Pipestone is located.
• Pipestone National Monument, located just outside the town of Pipestone.
• Catlinite, a type of red, carvable rock that was used by Native Americans for pipes and effigies.