Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P₃) commonly abbreviated to PIP₃ is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on Phosphatidylinositol (4,5)-bisphosphate.

PtdIns(3,4,5)P₃ is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring.

The PH domain in a number of proteins binds to PtdIns(3,4,5)P₃ include those in PKB, PDK1, Btk1 and ARNO. The generation of PtdIns(3,4,5)P₃ at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins translocate to the plasma membrane and accordingly effects their activity.

See also

Phosphatidylinositol 3-phosphate

Phosphatidylinositol 4-phosphate

Phosphatidylinositol 5-phosphate

Phosphatidylinositol (3,4)-bisphosphate

Phosphatidylinositol (4,5)-bisphosphate

Phosphatidylinositol (3,5)-bisphosphate