diamond-shaped plates ethanol (slightly), mineral oil (slightly)

Phenothiazine
General
Systematic name	10H-phenothiazine
Other names	thiodiphenylamine, dibenzothiazine
Molecular formula	C12H9NS
SMILES	?
Molar mass	199.2762 g/mol
Appearance	yellow rhombic leaflets or
CAS number	92-84-2
Properties
Density and phase	? g/cm3, solid at STP
Soluble	benzene, ether, hot acetic acid,
Insoluble	water, petroleum ether, chloroform
Melting point	185 °C
Boiling point	371 °C
Acidity (pKa)	2.520
Basicity (pKb)	?
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Chemical infobox

Phenothiazine (a phenol derivative of thiazine) is a pesticide and industrial chemical used in pharmaceutical manufacturing. It is sometimes used an antihelminthic. It was introduced by DuPont as an insecticide in 1935. It is now most commonly used as an intermediate chemical in the manufacture of various psychiatric drugs.

Phenothiazine-derivative drugs

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The word "phenothiazines" is used to describe the largest of the five main classes of antipsychotic drugs. Although these drugs are generally effective, there are often serious side effects including tardive dyskinesia and sedation (especially in the early stages of treatment).

There are three groups of phenothiazines, differing by their chemical structure and their pharmacological effects:

Group	Autonomic	Example	Sedative	Extrapyramidal side-effect
Aliphatic compounds
	moderate	Chlorpromazine (Thorazine, Largactil)	strong	moderate
		Promazine	moderate	moderate
		Triflupromazine (Vesprin)	strong	moderate/strong
		Levomepromazine (Nozinan)	extremely strong	low
Piperidines	strong	Mesoridazine	strong	weak
		Thioridazine (Mellaril)	strong	weak
Piperazines	weak	Fluphenazine	weak/moderate	strong
		Perphenazine	weak/moderate	strong
		Prochlorperazine (Compazine, Stemetil)
		Trifluoperazine (Stelazine)	moderate	strong

References

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• PubChem Substance Summary: Phenothiazine National Center for Biotechnology Information.

1. History of Insecticides and Control Equipment Clemson University Pesticide Information Program.
2. Hendricks, Christensen, J.B., and Kristiansen, Jette E. Sonderborg, Denmark. "Antibakterielle Eigenschaften der Phenothiazine: Eine Behandlungsoption für die Zukunft?" Chemotherapie Journal. 13.5. (2004): 203–205. Wissenschaftliche Verlagsgesesellschaft mbH. 21 August 2005. (PDF).

Phenothiazines

Phenothiazine | Phénothiazine | Phénothiazines | 酚噻嗪类抗精神分裂药