The pancreatic duct, or Duct of Wirsung, is a duct joining the pancreas to the bile duct to supply pancreatic juices which aid in digestion provided by the "exocrine pancreas". Most people have one pancreatic duct, which joins the biliary tract just prior to the ampulla of Vater. Many others have an additional "accessory pancreatic duct", called Duct of Santorini, which connects straight to the duodenum. Both these ducts connect to the second part (the vertical one) of the duodenum.

Compression, obstruction or inflammation of the pancreatic duct may lead to acute pancreatitis. The most common cause for obstruction is gallstones.

Digestive system