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The p110α protein is a class I PI 3-kinase catalytic subunit.
The human p110α protein is encoded by the PIK3CA gene. Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. Due to the association between p110α and cancer it is believed to be a promising drug target. A number of pharmaceutical companies are currently designing and charactering potential p110α isoform specific inhibitors.
See also
phosphoinositide 3-kinase
References
- Stein RC ( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 *
- Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.*
- Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM., Riggins GJ., Willson JK.V., Markowitz S, Kinzler KW., Vogelstein B, Velculescu VE. (2004) High Frequency of Mutations of the PIK3CA Gene in Human Cancers Science 304: 554 PMID: 15016963requires free registration
- Li VS, Wong CW, Chan TL, Chan AS, Zhao W, Chu KM, So S, Chen X, Yuen ST, Leung SY. (2005) Mutations of PIK3CA in gastric adenocarcinoma. BMC Cancer. 2005 5:29. PMID:15784156*
"P110α"