Nicorandil is a drug used to treat coronary heart disease. It is marketed as Ikorel ®.

It acts by relaxing the smooth muscle of the coronary arteries. It does this by activation of potassium channels, as well as activation of guanylate cyclase.

Reference

• Kukovetz WR et al (1992). Molecular mechanism of action of nicorandil. Journal of Cardiovascular Pharmacology 20 Suppl.3:S1-S7.