A multivitamin is any preparation containing more than a single vitamin. Tablets and injectable forms (for example Vitaped and Hospira) are available. In common usage, "multivitamin" refers to tablets that contain various vitamins usually along with dietary minerals and, occasionally, herbal extracts.
Orthomolecular medicine proponents generally recommend higher, individually optimized vitamin intakes. They recommend more absorbable forms of vitamins and minerals, in inexpensive but higher potency formulas, spread across the day. Often iron-free formulas, sometimes copper-free formulas are preferred.
Multivitamins may rarely be toxic if large doses of various vitamins or minerals are taken. In particular, these include vitamin A, vitamin D, vitamin B6, iron, and potassium. Total iron content of the whole bottle is the primary concern for child safety. There also are strict limits on the retinol content for vitamin A during pregnancy that are specifically addressed by prenatal formulas. This list is not exhaustive. Additionally, various medical conditions and medications may adversely interact with multivitamins. For normal adults taking a multivitamin for general health purposes, conventional medicine and government authorities recommend that a multivitamin should contain 100% DRI or less for each ingredient. However, many common brand supplements in the US use 100% - 200% of the DRI for certain vitamins or minerals. Higher potency versions of multivitamins, sometimes labelled as megavitamins, are available in the US.
However, some multivitamins contain very high doses of one or several vitamins or minerals and therefore require a prescription in the U.S. Since such drugs contain no new substances, they do not require the same testing as would be required by a New Drug Application, but were allowed on the market as drugs due to the FDA's Drug Efficacy Study Implementation program. See 36 Fed. Reg. 6843 (Apr. 9, 1971).
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