Monoarthritis is inflammation (arthritis) of one joint at a time. It is usually caused by gout, pseudogout or septic arthritis. Rarer causes include familial Mediterranean fever (FMF).

Diagnosis

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When faced with monoarthritis, one of the main decisions to make is whether to perform a joint aspirate by inserting a needle into the affected joint and removing some fluid for microscopic analysis. This decision is largely taken on inflammatory markers in blood tests (e.g. CRP), fever and the clinical picture. The main use of aspiration is to detect bacteria and neutrophil granulocytes (in septic arthritis) and crystals (crystal arthropathies).

Causes

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Septic arthritis

Septic arthritis is due to a bacterial infection to the joint. It requires urgent antibiotic therapy.

Gout

In gout, the acute inflammatory arthritis is caused by excess uric acid caused by either overproduction or under-excretion. Before the age of menopause, women have a lower incidence than males, but the rates are equal above this age. Gout can cause mono- or polyarthritis, but usually results in monoarthritis first.

Pseudogout

When monoarthritis is caused by pseudogout (calcium pyrophosphate deposition disease, CPPD), the inflammation usually lasts days to weeks, and involves the knees in half of all attacks. Like gout, attacks can occur spontaneously or with physical trauma or metabolic stress. Patients may feel well in between pseudogout attacks, and 5% present with pseudo-rheumatoid symptoms.

See also

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• Gout
• Pseudogout
• Septic arthritis

Rheumatology | Symptoms