Lincosamides (eg. Lincomycin, Clindamycin) are a class of drugs which bind to 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction. In this sense they have a similar action to macrolides.

Resistance

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Target bacteria may alter the drug's target site (similar to resistance found in macrolides and streptogramins). Also, enzymatic inactivation of clindamycin has been described (rare).

Pharmacodynamics

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These are bacteriostatic drugs and antagonists of macrolides and streptogramins.

Further reading

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Van Bambeke F. Mechanisms of action. In Armstrong D, Cohen J. Infectious diseases. Mosby, London, 1999, pp7/1.1-7/1.14

Lincosamid