The homeostatic model assessment (HOMA) is a method used to quantify insulin resistance. It was first described by Matthews et al in 1985.

Derivation

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Using a fasting blood sample, it is derived by use of the insulin-glucose product, divided by a constant:

Glucose (mg/dL)) x Insulin (µU/mL) / 405

In this equation, one should use the constant 22.5 instead of 405 if the glucose is reported in mmol/L. This model correlates well with estimates using the euglycemic clamp method (r = 0.88).

Source

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• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9. PMID 3899825.

Diabetes | Endocrinology