Glycopeptide antibiotics are a class of antibiotic drugs. They consist of a glycosylated cyclic or polycyclic nonribosomal peptide. Important glycopeptide antibiotics include vancomycin, teicoplanin, ramoplanin, and decaplanin.

This class of drugs inhibit the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan synthesis. Due to their toxicity, their use is restricted to those patients who are critically ill or who have a demonstrated hypersensitivity to the β-lactams. Principally effective against gram positive cocci, they exhibit a narrow spectrum of action. They are the last line of effective defence in MRSA.

Vancomycin is usually given intravenously and can cause tissue necrosis and phlebitis at the injection site is given to rapidly, indeed pain at site of injection is a common adverse event.

Glycopeptide antibiotics