A fusion inhibitor is a class of antiretroviral drugs used to treat HIV. It works by blocking HIV from fusing with a cell's membrane to enter and infect it.

Enfuvirtide: Enfuvirtide, also called T-20, is a fusion inhibitor with the trade name Fuzeon®.

For example, HIV binds to host cell receptor CD4+ by the protein GP120. Upon binding GP120 deforms allowing the viral protein GP41 to inbed it'self into the host cell's plasma membrane, entry inhibitors bind to GP41 preventing the creation of an entry pore for the capsid of the virus keeping it out of the cell. ^*

External links

• Fusion Inhibitor Resource Center