Erythema multiforme is a skin condition of unknown etiology that usually follows an antecedent infection or drug exposure. It varies from a mild, self-limited rash (E. multiforme minor) to a severe, life-threatening form (E. multiforme major, or Stevens-Johnson syndrome) that also involves mucous membranes.

The skin form of E. multiforme, far more common than the severe form, usually presents with mildly itchy, pink-red blotches, symmetrically arranged and starting on the extremities. It often takes the classical "target lesion" appearance, with a pink-red ring around a pale center. Resolution within 7-10 days is the norm.

The most common predisposing infection is Herpes simplex, but bacterial infections (commonly Mycoplasma) and fungal diseases are also implicated. E. multiforme may also be caused by drug reactions, most commonly Sulfa drugs, or a host of internal ailments.