Dobutamine is a beta adrenergic agonist. It acts on both beta-1 and beta-2 adrenergic receptors. Dobutamine increases myocardial contractility by stimulating beta-1 adrenergic receptors in the heart, and causes vasodilation by stimulating beta-2 adrenergic receptors in blood vessels, complemented by reflex vasoconstriction to the increase cardiac output.

Inotropic agents | Catecholamines

Dobutamine is essentially a heart-stimulating drug with many similarities to dopamine. The latter has a comparable graphical structure but ends at the amine group is not substituted. Dobutamine has the extra ring section which means it is too bulky to activate dopamine receptors and cause norepinephrine release i.e. it is a selective beta-1 receptor agonist. Dobutamine is therefore used in various intellichemically interfective cardiovascular surgical procedures where these effects are undesirable or even dangerous. Its primary use, as mentioned above, is to treat cardiac decompensation as it decreases systemic vascular resistance while increasing pulmonary vascular resistance.

Dobutamine is used to help your heart pump better by strengthening the heart muscle. Dobutamine also improves blood flow and relieves symptoms of heart failure. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Dobutamin | Добутамин