Deuce may refer to:

• The number two
• DEUCE, a British commercial computer built by English Electric in the 1950s
• Deuce McAllister, an American football player for the New Orleans Saints
• Deuce (character), a character from the webcomic Jerkcity

In sports and card games

• A playing card with the number two; in most games the lowest-ranked card
• Deuce-to-seven low, a method for evaluating low hands in poker
• A term used in tennis to refer to a 40-40 score, see Tennis: History

In entertainment:

• Male Gigolo, a 1999 comedy film starring Rob Schneider
• Little Deuce Coupe, a 1963 album by The Beach Boys
• Fire Deuce, a musical band who Travis Stever is a part of
• Deuces Wild, a 2002 film starring Johnny Knoxville
• Deuce (band), a UK pop band from the mid 90's
• Deuce (album), an album by rapper The D.O.C.
• ESPN 2, a sports television network nicknamed "the deuce"

Deuce may also refer to:

• Deuce coupe, a slang term for the Ford Model B car
• The 'common name' for the Harley-Davidson FXSTD/FXSTDI model motorcycle
• "The Deuce" or "Ace Deuce", nicknames for Ann Arbor, Michigan
• "Deuce and a half", a slang term for the U.S. Army's M-35 military
• A slang term for feces, related to the euphemism "Number 2".
• A name for the devil, usually used as a mild oath, for example, "What the deuce is going on here?" and "What the Deuce?"