Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence.

Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate. It should not be used in people with urinary retention.

Administration

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Darifenacin is administered as a once-daily extended-release oral tablet.

Side effects

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• Blurred vision
• Decreased sweating, possibly leading to heat prostration

Muscarinic antagonists