Cortisone is a steroid hormone. Chemically, it is a corticosteroid with formula C₂₁H₂₈O₅ and IUPAC name 17-hydroxy-11-dehydrocorticosterone. It is closely related to corticosterone.

Cortisone and adrenaline are the main hormones released by the body as a reaction to stress. They elevate blood pressure and prepare the body for a fight or flight response.

Cortisone is the inactive precursor molecule of the active hormone cortisol. It is activated through hydroxylation of the 11-keto-group by an enzyme called 11-beta-steroid dehydrogenase. The active form cortisol is thus sometimes referred to as hydrocortisone.

Cortisone is sometimes used as a drug to treat a variety of ailments. It can be administered intravenously or cutaneously.

One of cortisone's effects on the body, and a potentially harmful side effect when administered clinically, is the suppression of the immune system. This is an explanation for the apparent correlation between high stress and sickness.

Cortisone is less important than a similar steroid cortisol. Cortisol is responsible for 95% of the effects of the gluccocorticosteroids while cortisone is about 4 or 5%. Corticosterone is even less important.

Cortisone was first discovered by the American chemist Edward Calvin Kendall. He won a Nobel Prize for Physiology or Medicine along with Philip S. Hench and Tadeus Reichstein for the discovery of the hormones of the adrenal cortex, their structure and function.

Reference

• Merck Index, 11th Edition, 2533

See also

• Central serous retinopathy

External links

• Cortisone: The Wonder Drug

Corticosteroids

cortison | Cortisone | קורטיזון | Kortyzon | cortisona | Кортизон | Kortisoni | Cortisone