Cisapride

cis-4-amino-5-chloro-N-*-3-methoxy-4-piperidinyl]- 2-methoxybenzamide
CAS number 81098-60-4	ATC code A03FA02
Chemical formula	C23H29ClFN3O4
Molecular weight	465.9
Bioavailability	~100%
Metabolism	hepatic, intestinal
Elimination half life	10 hours
Excretion	renal, biliary
Pregnancy category	B1 (Australia)
Legal status	Schedule 4 (Australia)
Delivery	tablets, suspension

Cisapride is a parasympathomimetic which acts as a serotonin 5-HT₄ agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It is sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.).

Clinical uses

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Cisapride increases muscle tone in the esophageal sphincter in people with gastroesophageal reflux disease. It also increases gastric emptying in people with diabetic gastroparesis. It has been used to treat bowel constipation.

In many countries it has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias.

Sources

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• Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
• Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

Motility stimulants

Withdrawn drugs