Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3 % of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 16 probably contains between 850 and 1,200 genes.

Genes

---

The following are some of the genes located on chromosome 16:

• ABCC6: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
• CREBBP: CREB binding protein (Rubinstein-Taybi syndrome)
• GAN: giant axonal neuropathy (gigaxonin)
• LITAF: lipopolysaccharide-induced TNF factor
• MEFV: Mediterranean fever
• PKD1: polycystic kidney disease 1 (autosomal dominant)
• TAT: tyrosine aminotransferase
• TSC2: tuberous sclerosis 2

Diseases

---

The following diseases are some of those related to genes on chromosome 16:

• Charcot-Marie-Tooth disease
• Charcot-Marie-Tooth disease, type 1
• familial Mediterranean fever
• giant axonal neuropathy
• polycystic kidney disease
• pseudoxanthoma elasticum
• Rubinstein-Taybi syndrome
• tuberous sclerosis
• tyrosinemia

References

---

Chromosomes

Chromosome 16 humain | Humán 16-os kromoszóma | Cromossoma 16 (humano) | Хромозом 16 (човек)