A cholinergic crisis is an over-stimulation at a neuromuscular junction due to an excess of acetylcholine, as of a result of the inactivity (perhaps even inhibition) of the AChE enzyme, which normally breaks down acetylcholine. This is a consequence of some types of nerve gas. In medicine, this is seen in patients with myasthenia gravis who take too high a dose of their anticholinergic treatment medications. As a result of cholinergic crisis, muscles stop responding to the bombardment of Ach, leading to flaccid paralysis, respiratory failure, and other signs and symptoms reminiscent of organophosphate poisoning.