Cefalexin (INN) (IPA: ) or cephalexin (USAN) is a first-generation cephalosporin antibiotic. It is an orally-administered agent with a similar antimicrobial spectrum to the intravenous agents cefalotin and cefazolin. It is commonly marketed under the trade name Keflex (Lilly).

Clinical use

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Indications

Cefalexin is used to treat urinary tract infections, respiratory tract infections (including sinusitis, otitis media, pharyngitis, tonsillitis and pneumonia), skin and soft tissue infections.

Although it is not generally considered first-line therapy for any indication, it is a useful alternative to penicillins in patients with penicillin hypersensitivity. There is, however, cross-reactivity in 10% of patients with hypersensitivity to penicillins and carbapenems.

Formulations

Cefalexin is commonly marketed as capsules (250 mg and 500 mg), tablets, and powder for oral suspension (125 mg/5 mL and 250 mg/5 mL).

It is marketed by generic pharmaceutical manufacturers under a wide range of brand names, including: Apo-Cephalex, Biocef, Cefanox, Ceporex, Cilex, Keflet, Keflex, Keforal, Keftab, Keftal, Lopilexin, and Panixine Disperdose.

See also

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• Cephalosporin
• Cefazolin

External links

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• MedlinePlus Drug Information: Cephalosporins (systemic) – information from USP DI Advice for the Patient
• FDA Drug Information PDF and Pharmacy Drug Information Insert.

Cephalosporin antibiotics

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