Azaspirodecanediones are a class of drugs with anxiolytic effects used in the treatment of anxiety. Azaspirodecanediones have fewer side effects than some other common antianxiety drugs such as benzodiazepines. Unlike benzodiazepines, azaspirodecanediones are not addictive and do not induce tolerance. They are thought to agonize serotonin (specifically the 5-HT1A receptor), primarily in the hippocampus.

The common azaspirodecanediones used include buspirone (Buspar), gepirone, and ipsapirone.

Anxiolytics