Ataxia-telangiectasia mutated (ATM) is a serine/threonine-specific protein kinase that is recruited and activated by double stranded breaks of DNA and the MRN complex. It phosphorylates several key proteins that initiate cell cycle arrest, DNA repair or apoptosis. Several of these targets, including TP53, CHEK2, BRCA1, and H2AFX are tumor suppressors.

External links

• http://www.hprd.org/protein/06347

EC 2.7.1