Aβ is formed after sequential cleavage of the amyloid precursor protein (APP) by the β- and γ-secretases. APP is a transmembrane glycoprotein. Autosomal-dominant mutations in APP cause hereditary early-onset Alzheimer's disease, likely as a result of altered proteolytic processing. Increases in either total Aβ levels or the relative concentration of the 42-amino acid form have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease.

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Neuroscience | Enzymes | Integral membrane proteins | Biochemistry | Alzheimer's disease

Beta-amyloidi