Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. It contains the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces helical peptide structures. The peptide sequence is:

Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl

(Ac = acetyl, Phl = phenylalaninol)

CAS number: 27061-78-5

In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules.

Vendors' product pages

• Alamethicin from Fermentek
• Alamethicin from AGScientific

Polypeptide antibiotics