Agouti-related protein (AGRP) is a protein in the brain first identified by Ollmann et. al. It is a potent antagonist of MC3-R and MC4-R and is involved in the metabolic processes that regulate feeding behavior and body weight. It has been found in the hypothalamus. AGRP levels are elevated in obese males (Katsuki et al, 2001).

References

• Ollmann, M. M.; Wilson, B. D.; Yang, Y.-K.; Kerns, J. A.; Chen, Y.; Gantz, I.; Barsh, G. S. : Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278: 135-138, 1997.
• Katsuki, A.; Sumida, Y.; Gabazza, E. C.; Murashima, S.; Tanaka, T.; Furuta, M.; Araki-Sasaki, R.; Hori, Y.; Nakatani, K.; Yano, Y.; Adachi, Y. : Plasma levels of agouti-related protein are increased in obese men. J. Clin. Endocr. Metab. 86: 1921-1924, 2001.

See also

• Agouti-related peptide

External links

• http://www.phoenixpeptide.com/allobesity/Catalog%20Files/AGRP%20Section/AGRPNEW.htm

Proteins