Wyeth as a surname may refer to:

• a member of the Wyeth Family of American artists: father N.C. Wyeth (1882–1945), son Andrew Wyeth (born 1917), daughter Henriette Wyeth (1907–1997), grandson Jamie Wyeth (born 1946)
• Nathaniel Jarvis Wyeth (1802–1856), an American inventor, ice harvester, and explorer and trader

Wyeth may also refer to:

• Wyeth (formerly known as "American Home Products"), an American pharmaceutical company founded in 1860 by John and Frank Wyeth