Wade Hampton may refer to:

• Wade Hampton I (1752-1835), American soldier in Revolutionary War and War of 1812
• Wade Hampton II (1791-1858), American plantation owner and soldier in War of 1812
• Wade Hampton III (1818-1902), American Civil War soldier and politician; elected Governor and Senator from South Carolina and known as the "Savior of South Carolina" for his opposition to Reconstruction

Wade Hampton may also refer to the following geographical entities, both named after Wade Hampton III:

• Wade Hampton, South Carolina
• Wade Hampton Census Area, Alaska