WLS is a three-letter abbreviation with multiple meanings, as described below:

• The base callsign of two broadcast stations in Chicago, Illinois:
  • WLS (AM), the radio station at 890 kHz
  • WLS-TV, the TV station on analog channel 7 and digital channel 52
  • WLS-FM on 94.7 is now WZZN
  • Both callsigns date back to when Sears, Roebuck and Company owned both stations, and stood for: Worlds Largest Store.
• Weight loss surgery: see Roux-en-Y gastric bypass surgery.
• Weighted least squares, in computer science, is a method for model fitting.

WLS