Vogt-Koyanagi-Harada syndrome (VKH syndrome) is a condition seen in humans and dogs characterized by uveitis (inflammation of the inside of the eye), poliosis (whitening of hair), vitiligo (loss of pigment in the skin), and meningitis, although dogs with this syndrome rarely develop meningitis. It is also known as uveodermatologic syndrome. In humans there is a higher rate of VKH syndrome in people of Asian, Latin, and Mediterranean descent. In dogs it most commonly affects young animals and is seen in the Akita Inu, but also in the Siberian Husky and Samoyed.

VKH syndrome in dogs

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VKH syndrome is an immune-mediated disease. Uveitis usually occurs first and is often severe enough to cause blindness. VKH syndrome can also cause retinal detachment, cataracts, and glaucoma. Pigment partly disappears from the retinal pigment epithelium and iris. Skin lesions include loss of pigment and hair on the eyelids, nose, and lips. Symptoms and biopsy will confirm the diagnosis. Treatment is with immunosuppressive drugs such as prednisone and azathioprine. The prognosis is guarded.

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Dog health