USC may refer to:

In education:

• United Services College (Westward Ho!, Devon, England)
• Universidad del Sagrado Corazón, or University of the Sacred Heart (San Juan, Puerto Rico)
• University of San Carlos (Cebu City, Cebu, Philippines)
• University of Santiago de Compostela (Santiago de Compostela, Spain)
• University of South Carolina (South Carolina, USA)
• University of Southern California (Los Angeles, California, USA)
• University of the Sunshine Coast (Queensland, Australia)

In law:

• UN Security Council, an organ of the United Nations
• United States Code, a compilation and codification of the general and permanent federal Law of the United States
• United States Congress, the legislative branch of the federal government of the United States
• United States Constitution, the supreme law of the United States of America

In law enforcement:

• Ulster Special Constabulary, a former reserve police force in Northern Ireland
• United States Constabulary, the security force of the U.S. Occupation Zone of West Germany

In politics:

• United Somali Congress

USC