The longer of Maryland's two sections of U.S. Route 50 serves as a major route connecting Washington, DC with Ocean City. The other section is in Garrett County. Some major towns and cities in Maryland served by the route include Bowie, Annapolis, Easton, Cambridge, Salisbury, and Ocean City.
| # | Destinations | Notes |
|---|---|---|
| Baltimore-Washington Parkway - Baltimore (Maryland Route 295 north) | eastbound exit and westbound entrance; B-W Parkway joins westbound and splits eastbound | |
| Maryland Route 201 south to Interstate 295; Kenilworth Avenue; Southeast Washington, DC | ||
| Maryland Route 201 north - Kenilworth Avenue (Maryland Route 459) | ||
| Cheverly; Metro Station (Maryland Route 459) | ||
| Maryland Route 202 - Landover Road; Upper Marlboro; Bladensburg | ||
| 5 | Maryland Route 410 - East-West Highway to Ardwick Ardmore Road||
| New Carrollton Station (U.S. Route 50PA; Maryland Route 950) | no eastbound exit | |
| 7 | I-495.svg Interstate 95; Interstate 495 - Capital Beltway; Baltimore; Richmondsplit into 7A (south) and 7B (north) | |
| 8 | Maryland Route 704 - Martin Luther King Jr. Highway; Glenarden||
| 11 | Maryland Route 197 - Collington Road; Bowie||
| 13 | U.S. Route 301 south; MD Route 3.svg Maryland Route 3 north - Richmond; Crofton (Maryland Route 3E)split into 13A (US 301 south), 13B (MD 3 north) and 13C (Belair Drive); US 301 joins eastbound and leaves westbound | |
| 16 | Maryland Route 424 - Davidsonville Road; Davidsonville; Crofton||
| 21 | Interstate 97 north - Baltimore||
| 22 | Maryland Route 665 - Aris T. Allen Boulevard to Riva Road||
| 23B | Maryland Route 450 to MD Route 178.svg Maryland Route 178 - Parole; Crownsvilleexit 23 eastbound | |
| 23A | Maryland Route 2 south; MD Route 450.svg Maryland Route 450 - Parole; Jennifer RoadMD 2 joins eastbound and leaves westbound | |
| 24 | Maryland Route 70 - Rowe Boulevard; Bestgate Road; Annapolissplit into 24A (MD 70 south) and 24B (Bestgate Road) westbound | |
| Severn River Bridge | ||
| 27 | Maryland Route 2 north; MD Route 450.svg Maryland Route 450 south - Ritchie Highway; Baltimore; Severna Park; Naval Academysplit into 27A (MD 450 south) and 27B (MD 2 north) westbound; MD 2 joins westbound and leaves eastbound | |
| Maryland Route 648 north - Baltimore-Annapolis Boulevard | westbound exit and entrance | |
| 28 | Bay Dale Drive | |
| 29 | Maryland Route 179 - St. Margarets Road; Busch's Frontage Road; Cape St. Claire Road; East College Parkway (Maryland Route 908A; Maryland Route 931Q)split into 29A (MD 179) and 29B (Cape St. Claire Road) eastbound | |
| 30 | Whitehall Road (Maryland Route 908C) | eastbound exit and entrance |
| 31 | Whitehall Road (Maryland Route 908C) | eastbound exit and entrance |
| 32 | Sandy Point State Park; East College Parkway; Whitehall Road (Maryland Route 908B; Maryland Route 908D) | |
| Chesapeake Bay Bridge toll plaza ($2.50 cars - eastbound only) | ||
| 37 | Maryland Route 8 - Stevensville; Romancoke||
| 38A | Thompson Creek Road (Maryland Route 835A) | eastbound exit and entrance |
| 38A | Duke Street | westbound exit and entrance |
| (38B) | Services (U.S. Route 50QC) | westbound exit and entrance |
| 39A | Cox Neck Road | eastbound exit and entrance |
| 39A | Maryland Route 18 (Maryland Route 18H)westbound exit and entrance | |
| 39B | Maryland Route 552 - Dominion Roadeastbound exit and entrance | |
| 39B | Piney Creek Road (Maryland Route 18T; Maryland Route 552A) | westbound exit and entrance |
| 40A | South Piney Road | eastbound exit and entrance |
| 40A | Piney Creek Road | westbound exit and entrance |
| 40B | Dundee Avenue | eastbound exit and entrance |
| 41 | Maryland Route 18 - Main Street; Kent Narrows West||
| Kent Narrows Bridge | ||
| 42 | Maryland Route 18 - Main Street; Kent Narrows East (Maryland Route 835; Maryland Route 835G)||
| 43A | Maryland Route 18 - Main Street; Grasonville (Maryland Route 18F)eastbound exit and entrance | |
| 43A | Jackson Creek Road (Maryland Route 18U; Maryland Route 835B) | westbound exit and entrance |
| 43B | Chester River Beach Road (Maryland Route 18V) | no westbound exit |
| 44A | Station Lane (Maryland Route 18I) | eastbound exit and entrance |
| 44A | VFW Avenue (Maryland Route 18W; Maryland Route 835H) | westbound exit and entrance |
| 44B | Evans Avenue (Maryland Route 18Z) | eastbound exit and entrance |
| 44B | Winchester Creek Road (Maryland Route 835H) | westbound exit and entrance |
| 45A | Hess Road (Maryland Route 18X; Maryland Route 18Y) | eastbound exit and entrance |
| 45A | Hissey Road (Maryland Route 835I; Maryland Route 835J) | westbound exit and entrance |
| 45B | Nesbit Road (Maryland Route 835J; Maryland Route 835K) | |
| U.S. Route 301 north - Wilmington | eastbound exit and westbound entrance; US 301 joins westbound and leaves eastbound | |
| U.S. Route 50 east - Ocean City | eastbound exit and westbound entrance | |
U.S. Highways in Maryland | Blue Star Memorial Highways | U.S. Route 50 | Northwestern Turnpike
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"U.S. Route 50 in Maryland".
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