The name Tyrone can refer to:

• A county in Northern Ireland; see County Tyrone
• An Earl of Tyrone
• A small steam train which runs between Bushmills and the Giant's Causeway in Northern Ireland.
• One of a number of places in the United States of America:
  • Tyrone, Georgia
  • Tyrone, Missouri
  • Tyrone, New Mexico (ghost town)
  • Tyrone, New York
  • Tyrone, Pennsylvania
  • Tyrone Township, Michigan
  • Tyrone Township, Pennsylvania
• A personal name
  • Tyrone Biggums, a recurring character portrayed by Dave Chappelle on his sketch comedy show Chappelle's Show.
• Tyrone is also a song by Erykah Badu