Tylenol PM is the trademark for a mixture of paracetamol(acetaminophen) and diphenhydramine, distributed by Johnson & Johnson. It is marketed as a combined analgesic and sedative, or more simply, pain reliever and sleep aid, intended to treat occasional headaches and minor aches and pains with accompanying sleeplessness.

Acetaminophen alone is sold as simply Tylenol, while diphenhydramine alone is marketed at Simply Sleep.